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Influence of therapeutic doses of amoxicillin on aerobic work capacity and some strength characteristics

Department of Physiology, Biomedical Centre, University of Limburg, Maastricht, The Netherlands

Frans T.J. Verstappen, Ph.D.

Department of Physiology, Biomedical Centre, University of Limburg, Maastricht, The Netherlands

Robert S. Reneman, Ph.D.

Department of Physiology, Biomedical Centre, University of Limburg, Maastricht, The Netherlands

The purpose of this study was to investigate whether or not amoxicillin in therapeutic doses could have an influence on maximal aerobic work capacity and some strength character istics in trained subjects.

Fifteen volunteers (men; age range, 21 to 38 years; mean, 28.8 years) were examined once weekly for 4 consecutive weeks, and on these occasions the following variables and parameters were measured: maximum workload attained on the bicycle ergometer, maximum heart rate, maximum serum lactate concentration, heart rate and serum lactate concentra tion after 10 min at 80% of the maximum workload attained, maximum isometric extension force of the legs, vertical jump height, and body weight. During the baseline period, the deter mined variables and parameters did not show any significant difference between Test 1 and Test 2. During the 3rd and 4th week of the test period, the subjects received at random either placebo (6-aminopenicillanic acid) or amoxicillin in therapeutic doses (375 mg, 3 times a day) every day for 5 days. After the third test in the 3rd week, there was a cross-over, ensuring that each volunteer was examined during placebo as well as during amoxicillin medication. The serum amoxicillin levels were de termined. After statistical analysis, no influence of amoxicillin or placebo on the parameters and physiologic variables was demonstrable.