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First published on December 28, 2005, doi:10.1177/0363546505282619
This version was published on March 1, 2006
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The American Journal of Sports Medicine 34:490-498 (2006)
© 2006 American Orthopaedic Society for Sports Medicine


Clinical Sports Medicine Update

Anterior Cruciate Ligament Injuries in Female Athletes

Part 2, A Meta-analysis of Neuromuscular Interventions Aimed at Injury Prevention

Timothy E. Hewett, PhD*,{dagger},{ddagger}, Kevin R. Ford, MS{dagger} and Gregory D. Myer, MS, CSCS{dagger}

From the {dagger} Cincinnati Children’s Hospital Research Foundation, Sports Medicine Biodynamics Center and Human Performance Laboratory, Cincinnati, Ohio, and the {ddagger} University of Cincinnati College of Medicine, Departments of Pediatrics, Orthopaedic Surgery and Rehabilitation Sciences, College of Allied Health Sciences, Cincinnati, Ohio

* Address correspondence to Timothy E. Hewett, PhD, Cincinnati Children’s Hospital, 3333 Burnet Avenue, MLC 10001, Cincinnati, OH 45229 (e-mail: tim.hewett{at}cchmc.org).

Female athletes have a 4 to 6 times higher incidence of anterior cruciate ligament injury than do male athletes participating in the same landing and pivoting sports. This greater risk of anterior cruciate ligament injury, coupled with a geometric increase in participation (doubling each decade), has led to a significant rise in anterior cruciate ligament injuries in female athletes. The gender gap in anterior cruciate ligament injury, combined with evidence that the underpinnings of this serious health problem are neuromuscular in nature, leads to the development of neuromuscular interventions designed to prevent injury. A systematic review of the published literature yielded 6 published interventions targeted toward anterior cruciate ligament injury prevention in female athletes. Four of 6 significantly reduced knee injury incidence, and 3 of 6 significantly reduced anterior cruciate ligament injury incidence in female athletes. A meta-analysis of these 6 studies demonstrates a significant effect of neuromuscular training programs on anterior cruciate ligament injury incidence in female athletes (test for overall effect, Z = 4.31, P < .0001). Examination of the similarities and differences between the training regimens gives insight into the development of more effective and efficient interventions. The purpose of this "Current Concepts" review is to highlight the relative effectiveness of these interventions in reducing anterior cruciate ligament injury rates and to evaluate the common training components between the training studies. In addition, the level of rigor of these interventions, the costs and the difficulty of implementation, the compliance with these interventions, and the performance benefits are discussed. This review summarizes conclusions based on evidence from the common components of the various interventions to discuss their potential to reduce anterior cruciate ligament injury risk and assess their potential for combined use in more effective and efficient intervention protocols.

Key Words: neuromuscular training • balance training • strength training • plyometrics • knee injury • anterior cruciate ligament (ACL) injury • injury prevention • gender differences




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