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* Gothenburg Medical Center, Gothenburg University, Gothenburg, Sweden
Kungsbacka Hospital, Gothenburg University, Gothenburg, Sweden
Department of Surgery, Jyväskylä Central Hospital, Jyväskylä, Finland
|| Department of Cell and Molecular Biology, University of Lund, Lund, Sweden
a Institute of Laboratory Medicine, Sahlgrenska University Hospital, Gothenburg, Sweden
Address correspondence and reprint requests to Lars Peterson, MD, PhD, Gothenburg Medical Center, Gruvgatan 6, SE-421 30 Västra Frölunda, Gothenburg, Sweden
We evaluated the durability of autologous chondrocyte transplantation grafts in 61 patients treated for isolated cartilage defects on the femoral condyle or the patella and followed up for a mean of 7.4 years (range, 5 to 11). Durability was determined by comparing the clinical status at the long-term follow-up with that found 2 years after the transplantation. After 2 years, 50 of the 61 patients had good or excellent clinical results, and 51 of 61 had good or excellent results at 5 to 11 years later. Grafted areas from 11 of the patients were evaluated with an electromechanical indentation probe during a second-look arthroscopy procedure (mean follow-up, 54.3 months; range, 33 to 84); stiffness measurements were 90% or more of those of normal cartilage in eight patients. Eight of twelve 2-mm biopsy samples taken from these patients showed hyaline characteristics with safranin O staining and a homogeneous appearance in polarized light. Three fibrous and eight hyaline biopsy specimens stained positive to aggrecan and to cartilage oligomeric matrix protein. Hyaline-like specimens stained positive for type II collagen, and fibrous, for type I collagen. Autologous chondrocyte transplantation for the treatment of articular cartilage injuries has a durable outcome for as long as 11 years.
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L. Peterson, T. Minas, M. Brittberg, and A. Lindahl Treatment of Osteochondritis Dissecans of the Knee with Autologous Chondrocyte Transplantation: Results at Two to Ten Years J. Bone Joint Surg. Am., April 28, 2003; 85(90002): 17 - 24. [Abstract] [Full Text]
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P. Mainil-Varlet, T. Aigner, M. Brittberg, P. Bullough, A. Hollander, E. Hunziker, R. Kandel, S. Nehrer, K. Pritzker, S. Roberts, et al. Histological Assessment of Cartilage Repair: A Report by the Histology Endpoint Committee of the International Cartilage Repair Society (ICRS) J. Bone Joint Surg. Am., April 28, 2003; 85(90002): 45 - 57. [Full Text]
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T. Tallheden, J. E. Dennis, D. P. Lennon, E. Sjogren-Jansson, A. I. Caplan, and A. Lindahl Phenotypic Plasticity of Human Articular Chondrocytes J. Bone Joint Surg. Am., April 28, 2003; 85(90002): 93 - 100. [Abstract] [Full Text]
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