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Effects of Hyperbaric Oxygen on a Human Model of Injury

James R. Staples, MSc^*, Douglas B. Clement, MD^,, Jack E. Taunton, MD and Donald C. McKenzie, MD, PhD

^* Faculty of Human Kinetics, Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada
Division of Sports Medicine, Allan McGavin Sports Medicine Centre, University of British Columbia, Vancouver, British Columbia, Canada

Address correspondence and reprint requests to Douglas B. Clement, MD, Allan McGavin Sports Medicine Centre, University of British Columbia, 3055 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 1Z3

To determine whether intermittent exposures to hyperbaric oxygen enhance recovery from delayed-onset muscle soreness of the quadriceps, we conducted a randomized, controlled, double-blinded, prospective study using 66 untrained men between the ages of 18 and 35 years. After the induction of muscle soreness, these subjects were treated in a hyperbaric chamber over a 5-day period in two phases, with four groups (control, hyperbaric oxygen treatment, delayed treatment, and sham treatment) in the first phase; and three groups (3 days of treatment, 5 days of treatment, and sham treatment) in the second phase. The hyperbaric exposures involved 100% oxygen for 1 hour per day at 2.0 atm. The sham treatments involved 21% oxygen for 1 hour per day at 1.2 atm. We monitored recovery using a leg dynamometer to test eccentric torque of the nondominant quadriceps muscle before and immediately after exercise and at 48 and 96 hours after exercise. Pain was tested daily using visual analog pain scales. In phase 1 a significant difference in recovery of eccentric torque was noted in the treatment group compared with the other groups. In phase 2, the recovery of eccentric torque for the 5-day treatment group was significantly greater than for the sham group from immediately after exercise to 96 hours after exercise. The pain data did not differ significantly in any comparison in either phase. The results suggest that treatment with hyperbaric oxygen may enhance recovery of eccentric torque of the quadriceps muscle from delayed-onset muscle soreness.

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