| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Sign In to gain access to subscriptions and/or personal tools.
|
|
|
|||||||
Sign In to gain access to subscriptions and/or personal tools. |
|||||||||
Duke Orthopaedic Research Laboratories, Department of Surgery, Duke University Medical Center, Durham, North Carolina
Duke Orthopaedic Research Laboratories, Department of Surgery, Duke University Medical Center, Durham, North Carolina
Duke Orthopaedic Research Laboratories, Department of Surgery, Duke University Medical Center, Durham, North Carolina
Duke Orthopaedic Research Laboratories, Department of Surgery, Duke University Medical Center, Durham, North Carolina
This study was designed to observe the effect of the nonsteroidal antiinflammatory piroxicam on a controlled muscle strain injury in the rabbit model. The tibialis an terior tendons of 90 New Zealand White rabbits were detached at their distal insertions, and the right tendon was stretched to the yield point of the deformation curve. One group of 50 rabbits received piroxicam treat ment and the others received no treatment. At 1, 2, 4, and 7 days the parameters of muscle function, tensile strength, and histology were examined. Muscle con tractile force was significantly greater in the piroxicam- treated group at Day 1, but no difference was noted at any other time period. Tensile strength was not signifi cantly different at any time period in either group. His tology revealed delayed degradation of damaged tissue and slowed regeneration of muscle tissue at the injury site in the piroxicam-treated group.
Piroxicam and other antiinflammatories are fre quently given to athletes being treated for muscle strain injuries to control pain through their effect on the in flammatory process. This study demonstrates that pi roxicam does not adversely influence the recovery of contractile and tensile strength in a followup period of 1 week. Therefore, antiinflammatory treatment may be beneficial early in the course of muscle injury.
This article has been cited by other articles:
|
|
 |
|
  J. Zhu, Y. Li, W. Shen, C. Qiao, F. Ambrosio, M. Lavasani, M. Nozaki, M. F. Branca, and J. Huard Relationships between Transforming Growth Factor-beta1, Myostatin, and Decorin: IMPLICATIONS FOR SKELETAL MUSCLE FIBROSIS J. Biol. Chem., August 31, 2007; 282(35): 25852 - 25863. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 D. Marsolais, E. Duchesne, C. H. Cote, and J. Frenette Inflammatory cells do not decrease the ultimate tensile strength of intact tendons in vivo and in vitro: protective role of mechanical loading J Appl Physiol, January 1, 2007; 102(1): 11 - 17. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
W. Shen, V. Prisk, Y. Li, W. Foster, and J. Huard Inhibited skeletal muscle healing in cyclooxygenase-2 gene-deficient mice: the role of PGE2 and PGF2{alpha} J Appl Physiol, October 1, 2006; 101(4): 1215 - 1221. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Shen, Y. Li, Y. Tang, J. Cummins, and J. Huard NS-398, a Cyclooxygenase-2-Specific Inhibitor, Delays Skeletal Muscle Healing by Decreasing Regeneration and Promoting Fibrosis Am. J. Pathol., October 1, 2005; 167(4): 1105 - 1117. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Vignaud, J Cebrian, I Martelly, J.-P Caruelle, and A Ferry Effect of anti-inflammatory and antioxidant drugs on the long-term repair of severely injured mouse skeletal muscle Exp Physiol, July 1, 2005; 90(4): 487 - 495. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 T. A. H. Jarvinen, T. L. N. Jarvinen, M. Kaariainen, H. Kalimo, and M. Jarvinen Muscle Injuries: Biology and Treatment Am. J. Sports Med., May 1, 2005; 33(5): 745 - 764. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. G. Tidball Inflammatory processes in muscle injury and repair Am J Physiol Regulatory Integrative Comp Physiol, February 1, 2005; 288(2): R345 - R353. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B. A. Bondesen, S. T. Mills, K. M. Kegley, and G. K. Pavlath The COX-2 pathway is essential during early stages of skeletal muscle regeneration Am J Physiol Cell Physiol, August 1, 2004; 287(2): C475 - C483. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H Toumi and T M Best The inflammatory response: friend or enemy for muscle injury? Br. J. Sports Med., August 1, 2003; 37(4): 284 - 286. [Full Text] [PDF]
|
|
|
|
|
|
W. N. Levine, J. A. Bergfeld, W. Tessendorf, and C. T. Moorman III Intramuscular Corticosteroid Injection for Hamstring Injuries: A 13-Year Experience in the National Football League Am. J. Sports Med., May 1, 2000; 28(3): 297 - 300. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. A. Kurtz, T. G. Loebig, D. D. Anderson, P. J. DeMeo, and P. G. Campbell Insulin-Like Growth Factor I Accelerates Functional Recovery from Achilles Tendon Injury in a Rat Model Am. J. Sports Med., May 1, 1999; 27(3): 363 - 369. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
