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Southern California Center for Sports Medicine, Long Beach Memorial Medical Center, Long Beach, California, Noyes-Giannestra Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio
Noyes-Giannestra Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio, Noyes-Giannestra Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio
Southern California Center for Sports Medicine, Long Beach Memorial Medical Center, Long Beach, California
Southern California Center for Sports Medicine, Long Beach Memorial Medical Center, Long Beach, California
Southern California Center for Sports Medicine, Long Beach Memorial Medical Center, Long Beach, California
Noyes-Giannestra Biomechanics Laboratory, University of Cincinnati, Cincinnati, Ohio
Southern California Center for Sports Medicine, Long Beach Memorial Medical Center, Long Beach, California
Similar-sized patellar tendon autografts and fresh-fro zen allografts were used to reconstruct the anterior cruciate ligament of one knee in 40 female goats. Evaluations of the reconstructions and contralateral controls at the 6-week and 6-month postoperative pe riods included anterior-posterior translation, mechanical properties determined during tensile failure tests, meas urement of cross-sectional area, histology, collagen fibril size and area distribution, and associated articular cartilage degenerative changes.
Six months after anterior cruciate ligament recon struction, the autografts demonstrated a smaller in crease in anterior-posterior displacement, values of maximum force to failure two times greater, a significant increase in cross-sectional area, a more rapid loss of large-diameter collagen fibrils, and an increased density and number of small-diameter collagen fibrils compared to the allografts.
Clinical significance . More surgeons are allowing their patients to return to running and sports 6 months after anterior cruciate ligament reconstruction. While the structural and material properties of autografts and allografts at time zero are similar, in the goat model during the first 6 months they differ. The allografts demonstrate a greater decrease in their implantation structural properties, a slower rate of biologic incorpo ration, and the prolonged presence of an inflammatory response. At 6 months the autograft demonstrates a more robust biologic response, improved stability, and increased strength to failure values.
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