| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
Sign In to gain access to subscriptions and/or personal tools.
|
|
|
|||||||
Sign In to gain access to subscriptions and/or personal tools. |
|||||||||
Southern California Center for Sports Medicine and Memorial Medical Center of Long Beach, Long Beach, California
Department of Musculoskeletal Research, Cleveland Clinic Foundation Research Institute, Cleveland, Ohio
Southern California Center for Sports Medicine and Memorial Medical Center of Long Beach, Long Beach, California
Laboratory of Comparative Orthopaedics, Hospital for Special Surgery, New York, New York
Southern California Center for Sports Medicine and Memorial Medical Center of Long Beach, Long Beach, California
Southern California Center for Sports Medicine and Memorial Medical Center of Long Beach, Long Beach, California
A comparative study of three subgroups of meniscal transplants was undertaken in the goat model: Group 1 (autograft) involved removal and immediate reimplan tation of the meniscus; Group 2, fresh meniscal allo grafts ; and Group 3, cryopreserved (30 days) meniscal allografts. Six months after surgery, tissues were eval uated for gross degenerative changes, proteoglycan concentration (as assessed by uronic acid), water con tent, vascularity, histology, and cell viability. The con tralateral knee served as control for all comparisons. There was no statistical difference in the amount of arthritis present and all transplants demonstrated an essentially normal peripheral vascularity compared to controls. Sections revealed reduced numbers of cells in the central portions of the transplanted menisci and these viable cells demonstrated different behavior in multiplication in tissue culture compared to contralateral controls.
Grossly and microscopically, the implanted menisci differed little from the controls. The measurement of proteoglycan concentration and water content of the transplanted meniscal cartilage suggest alterations that may affect the long-term mechanical properties. The autograft specimens showed the water content was very slightly increased (3% to 6%), while the proteogly can concentration was increased (42% in terms of uronic acid). In contrast, the water content of the fresh allograft group and the cryopreserved group was in creased 12% to 24%. Proteoglycan concentration in these groups was decreased up to 56% in portions of some menisci compared to controls.
Fresh and cryopreserved meniscal allografts showed peripheral healing, revascularization, cellularity, and in corporation, and grossly appeared good at 6 months in the goat model. The biochemical changes in the extra cellular matrix at 6 months raises questions on the long- term function of these transplanted menisci.
This article has been cited by other articles:
|
|
 |
|
  G. von Lewinski, D. Kohn, C. J. Wirth, and D. Lazovic The Influence of Nonanatomical Insertion and Incongruence of Meniscal Transplants on the Articular Cartilage in an Ovine Model Am. J. Sports Med., May 1, 2008; 36(5): 841 - 850. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Schimizzi, M. Wedemeyer, T. Odell, W. Thomas, A. T. Mahar, and R. Pedowitz Effects of a Novel Sterilization Process on Soft Tissue Mechanical Properties for Anterior Cruciate Ligament Allografts Am. J. Sports Med., April 1, 2007; 35(4): 612 - 616. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. T. Kelly, H. G. Potter, X.-H. Deng, A. D. Pearle, A. S. Turner, R. F. Warren, and S. A. Rodeo Meniscal Allograft Transplantation in the Sheep Knee: Evaluation of Chondroprotective Effects Am. J. Sports Med., September 1, 2006; 34(9): 1464 - 1477. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 J. K. Sekiya and C. I. Ellingson Meniscal allograft transplantation. J. Am. Acad. Ortho. Surg., March 1, 2006; 14(3): 164 - 174. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. von Lewinski, T. Pressel, C. Hurschler, and F. Witte The Influence of Intraoperative Pretensioning on the Chondroprotective Effect of Meniscal Transplants Am. J. Sports Med., March 1, 2006; 34(3): 397 - 406. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 F. R. Noyes, S. D. Barber-Westin, and M. Rankin Meniscal Transplantation in Symptomatic Patients Less Than Fifty Years Old J. Bone Joint Surg. Am., July 1, 2004; 86(7): 1392 - 1404. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. J. Cole, T. R. Carter, and S. A. Rodeo Allograft Meniscal Transplantation : Background, Techniques, and Results J. Bone Joint Surg. Am., July 9, 2002; 84(7): 1236 - 1250. [Full Text] [PDF]
|
|
|
|
|
|
P. E. Greis, M. C. Holmstrom, D. D. Bardana, and R. T. Burks Meniscal Injury: II. Management J. Am. Acad. Ortho. Surg., May 1, 2002; 10(3): 177 - 187. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Rath, J. C. Richmond, W. Yassir, J. D. Albright, and F. Gundogan Meniscal Allograft Transplantation: Two- to Eight-Year Results Am. J. Sports Med., July 1, 2001; 29(4): 410 - 414. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. L. SZOMOR, T. E. MARTIN, F. BONAR, and G. A. C. MURRELL The Protective Effects of Meniscal Transplantation on Cartilage. An Experimental Study in Sheep J. Bone Joint Surg. Am., January 1, 2000; 82(1): 80 - 8. [Abstract] [Full Text]
|
|
|
|
|
|
M. M. Alhalki, S. M. Howell, and M. L. Hull How Three Methods for Fixing a Medial Meniscal Autograft Affect Tibial Contact Mechanics Am. J. Sports Med., May 1, 1999; 27(3): 320 - 328. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. R. STONE, J. R. STEADMAN, W. G. RODKEY, and S.-T. LI Regeneration of Meniscal Cartilage with Use of a Collagen Scaffold. Analysis of Preliminary Data J. Bone Joint Surg. Am., December 1, 1997; 79(12): 1770 - 7. [Abstract] [Full Text]
|
|
|
|
|
|
D. J. Edwards, S. L. Whittle, M. J. Nissen, B. Cohen, R. D. Oakeshott, and G. C. R. Keene Radiographic Changes in the Knee After Meniscal Transplantation: An Experimental Study in a Sheep Model Am. J. Sports Med., March 1, 1996; 24(2): 222 - 226. [Abstract] [PDF]
|
|
|
|
|
|
D. W. Jackson, J. Whelan, and T. M. Simon Cell survival after transplantation of fresh meniscal allografts: DNA probe analysis in a goat model Am. J. Sports Med., July 1, 1993; 21(4): 540 - 550. [Abstract] [PDF]
|
|
| HOME | HELP | CONTACT US | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS |
